| 2021-09-25 | Leicester City - Burnley | Leicester City -0.75 | 2-2 | Lose |
| 2021-09-24 | Sporting Lisbon - Maritimo | Maritimo +1.5 | 1-0 | Win |
| 2021-09-23 | Granada - Real Sociedad | Real Sociedad -0.5 | 2-3 | Win |
| 2021-09-22 | Lille - Remis | Lille -0.75 | 2-1 | Win |
| 2021-09-21 | Levante - Celta Vigo | Celta Vigo -0 | 0-2 | Win |
| 2021-09-20 | Hammarby - Varbergs BoIS | Hammarby -1 | 3-1 | Win |
| 2021-09-19 | Lazio - Cagliar | Cagliar +1.25 | 2-2 | Win |
| 2021-09-18 | Akhmat Grozny - FC Krasnodar | FC Krasnodar -0 | 0-2 | Win |
| 2021-09-17 | Sassuolo - Torino | Sassuolo-0.5 | 0-1 | Lose |
| 2021-09-16 | HJK - LASK Linz | LASK Linz -0 | 0-2 | Win |
| 2021-09-15 | Atletico Madrid - Porto | Porto +1 | 0-0 | Win |
| 2021-09-14 | Young Boys - Man United | Man United -1 | 2-1 | Lose |
| 2021-09-13 | Rostov FK - FK Krasnodar | FK Krasnodar -0 | 0-2 | Win |
| 2021-09-12 | AS Roma - Sassuolo | Sassuolo +1 | 2-1 | Draw |
| 2021-09-11 | Crystal Palace - Tottenham | Crystal Palace +0.5 | 3-0 | Win |